Jean Ge focuses her practice on US and foreign patent prosecution and counseling for clients in the life sciences and biotechnology industries. Her experience includes strategic IP portfolio building and management, patentability and freedom to operate assessments, due diligence analyses, and invalidity analyses. She has extensive knowledge in the areas of antibodies, antibody fusion proteins, antibody-drug conjugates, nucleic acid-based therapeutics, cell-based therapies, and synthetic biology.

Prior to joining Wolf Greenfield, Jean held a postdoctoral fellowship at the National Heart, Lung, and Blood Institute (NHLBI), where she conducted research on the inhibition mechanism of Nonsense­-Mediated mRNA Decay (NMD) pathway and human gene regulation. Jean also completed an internship at the Office of Technology Transfer and Development (OTTAD) of NHLBI, where she gained experience in technology transfer and research commercialization in the federal government.

Client testimonial:
"Jean Ge is an impressive [attorney] who has a thorough grasp of our entire portfolio and how the pieces of that portfolio interrelate."
  • The RNA Society
  • Boston Patent Law Association
  • Law Dean's Scholarship, Suffolk University Law School, 2018-2021
  • Trustee Academic Scholarship, Suffolk University Law School, 2018-2021
  • NIH Intramural Research Training Award, National Institutes of Health, 2012

Blogs

March 30, 2021 - Wolf Tracks Life Science IP Blog - Finding the ‘Sweet Spot’ of Enablement in Amgen v. Sanofi: The Federal Circuit Provides Guidance on Enabling Antibody Claims 

April 24, 2017 - Wolf Greenfield Post Grant Blog - Magnitude of Comparative Results: What’s Considered Unexpected? 

Scientific Publications

Aparna Kishor, Sarah E Fritz, Nazmul Haque, Zhiyun Ge, Ilker Tunc, Wenjing Yang, Jun Zhu, J Robert Hogg (2020) Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products. Nucleic Acids Research, Volume 48, Issue 13, Pages 7468–7482,

Aparna Kishor, Zhiyun Ge, J Robert Hogg (2019) hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma. EMBO J;38(3):e99128.

Zhiyun Ge, Bao Lin Quek, Karen L Beemon, J Robert Hogg (2016) Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife;5:e11155.

Zhiyun Ge, Preeti Mehta, Jamie Richards, A Wali Karzai. (2010) Non-stop mRNA decay initiates at the ribosome. Mol Microbiol;78(5):1159-70.

Zhiyun Ge and A. Wali Karzai (2009) Co-Evolution of Multipartite Interactions Between an Extended tmRNA Tag and a Robust Lon Protease in Mycoplasma. Mol Microbiol.; 74(5): 1083–1099.

Thomas Sundermeier, Zhiyun Ge, Jamie Richards, Daniel Dulebohn, A Wali Karzai (2008) Studying tmRNA-mediated surveillance and nonstop mRNA decay. Methods Enzymol;447:329-58

 


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Jean Ge focuses her practice on US and foreign patent prosecution and counseling for clients in the life sciences and biotechnology industries. Her experience includes strategic IP portfolio building and management, patentability and freedom to operate assessments, due diligence analyses, and invalidity analyses. She has extensive knowledge in the areas of antibodies, antibody fusion proteins, antibody-drug conjugates, nucleic acid-based therapeutics, cell-based therapies, and synthetic biology.

Prior to joining Wolf Greenfield, Jean held a postdoctoral fellowship at the National Heart, Lung, and Blood Institute (NHLBI), where she conducted research on the inhibition mechanism of Nonsense­-Mediated mRNA Decay (NMD) pathway and human gene regulation. Jean also completed an internship at the Office of Technology Transfer and Development (OTTAD) of NHLBI, where she gained experience in technology transfer and research commercialization in the federal government.

Client testimonial:
"Jean Ge is an impressive [attorney] who has a thorough grasp of our entire portfolio and how the pieces of that portfolio interrelate."
  • The RNA Society
  • Boston Patent Law Association
  • Law Dean's Scholarship, Suffolk University Law School, 2018-2021
  • Trustee Academic Scholarship, Suffolk University Law School, 2018-2021
  • NIH Intramural Research Training Award, National Institutes of Health, 2012

Blogs

March 30, 2021 - Wolf Tracks Life Science IP Blog - Finding the ‘Sweet Spot’ of Enablement in Amgen v. Sanofi: The Federal Circuit Provides Guidance on Enabling Antibody Claims 

April 24, 2017 - Wolf Greenfield Post Grant Blog - Magnitude of Comparative Results: What’s Considered Unexpected? 

Scientific Publications

Aparna Kishor, Sarah E Fritz, Nazmul Haque, Zhiyun Ge, Ilker Tunc, Wenjing Yang, Jun Zhu, J Robert Hogg (2020) Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products. Nucleic Acids Research, Volume 48, Issue 13, Pages 7468–7482,

Aparna Kishor, Zhiyun Ge, J Robert Hogg (2019) hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma. EMBO J;38(3):e99128.

Zhiyun Ge, Bao Lin Quek, Karen L Beemon, J Robert Hogg (2016) Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. Elife;5:e11155.

Zhiyun Ge, Preeti Mehta, Jamie Richards, A Wali Karzai. (2010) Non-stop mRNA decay initiates at the ribosome. Mol Microbiol;78(5):1159-70.

Zhiyun Ge and A. Wali Karzai (2009) Co-Evolution of Multipartite Interactions Between an Extended tmRNA Tag and a Robust Lon Protease in Mycoplasma. Mol Microbiol.; 74(5): 1083–1099.

Thomas Sundermeier, Zhiyun Ge, Jamie Richards, Daniel Dulebohn, A Wali Karzai (2008) Studying tmRNA-mediated surveillance and nonstop mRNA decay. Methods Enzymol;447:329-58