Harold Silverman assists the firm in biotechnology patent prosecution. Harold has over a decade of experience in the area of bioelectronic medicine, including vagus nerve recording and stimulation. His experience also spans neurophysiology, neuromodulation, immunology, epidemiology, genetics, and biomedical anthropology.

A neuroscience enthusiast, Harold is passionate about applying his knowledge and experience in the integration of biology and technology to identify and advance projects with high potential for positive impact in the scientific, academic, and medical communities. He has a particular focus on working with start-ups to evaluate and accomplish their scientific and business goals.

Prior to joining Wolf Greenfield, Harold received his PhD in The Molecular Basis of Medicine from Zucker School of Medicine at Hofstra/Northwell, with a focus on the interaction between the nervous system and immune system in response to inflammation. As a graduate student researcher in the Feinstein Institutes Laboratory for Biomedical Sciences, he was involved in research discoveries that led to two preliminary patents.
  • Society for Neuroscience
  • New York Academy of Sciences


Scientific Publications

Yang, H., Zeng, Q., Silverman, H.A., Gunasekaran, M., George, S.J., Devarajan, A., Addorisio, M.E., Li, J., Tsaava, T., Shah, V. and Billiar, T.R., Wang, H., Brines, M., Andersson, U., Pavlov, P.A., Chang, E.H., Chavan, S.S., Tracey, K.J. (2021). HMGB1 released from nociceptors mediates inflammation. Proceedings of the National Academy of Sciences, 118(33).
DOI: 10.1073/pnas.2102034118

Silverman H.A., Chen A., Kravatz N.L., Chavan S.S., Chang E.H. (2020). Involvement of neural transient receptor potential channels in peripheral inflammation. Frontiers in Immunology, 11. eCollection 2020.
DOI: 10.3389/fimmu.2020.590261

Tsaava, T., Datta-Chaudhuri, T., Addorisio, M.E., Masi, E.B., Silverman, H.A., Newman, J.E., Imperato, G.H., Bouton, C.E., Tracey, K.J., Chavan, S.S., Chang, E.H. (2020). Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation. Bioelectronic Medicine, 6(1), 1-10.
DOI: 10.1186/s42234-020-00042-8

Lehner K.R., Silverman H.A., Addorisio M.E., Roy A., Al-Onaizi M.A., Levine Y., Olofsson P.S., Chavan S.S., Gros R., Nathanson N.M., Al-Abed Y.A., Metz C.N., Prado V.F., Tracey K.J., Pavlov V.A. (2019). Forebrain cholinergic signaling regulates innate immune responses and inflammation. Frontiers in Immunology. 10, 585.
DOI: 10.3389/fimmu.2019.00585

Zanos, T.P.*, Silverman H.A.*, Levy, T., Battinelli, E.A., Chavan, S.S., Tracey, K.J., Bouton, C.E. (2018). Identification of cytokine-specific neural signals by decoding murine vagus nerve activity. Proceedings of the National Academy of Sciences, 115 (21) E4843-E4852. DOI:10.1073/pnas.1719083115

Silverman, H.A., Stigler, A., Tsaava, T., Newnan, J., Steinberg, B.E., Battinelli, E.A., Robbiati, S., Bouton, C., Huerta, P.T., Chavan, S.S., Tracey, K.J. (2018). Standardization of methods to record vagus nerve activity in mice. Bioelectronic Medicine, 4(1), 1-13.
DOI: 10.1186/s42234-018-0002-y

Zaghloul N., Addorisio M., Silverman H.A., Patel H.L., Valdes Ferrer S.I., Ayasolla K.R., Lehner K.R.,Olofsson P.S., Nasim M., Metz C.N., Wang P., Ahmed M., Chavan S.S., Diamond B., Tracey K.J., Pavlov V.A.* (2017). Forebrain cholinergic dysfunction and systemic and brain inflammation in murine sepsis survivors. Frontiers in Immunology, 8.
DOI: 10.3389/fimmu.2017.01673

Caravaca, A.S., Tsaava, T., Goldman, L., Silverman, H., Riggott, G., Chavan, S., Bouton, C., Tracey, K.J., Desimone, R., Boyden, E., Sohal, H.S. and Olofsson, P.S. (2017). A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. Journal of Neural Engineering. 14(6), 066005.
DOI: 10.1088/1741-2552/aa7a42

Steinberg, B.E.*, Silverman, H.A.*, Robbiati, S., Gunasekaran, M.K., Tsaava, T., Battinelli, E., Stiegler, A., Bouton, C.E., Chavan, S.S., Tracey, K.J. and Huerta, P.T. (2016). Cytokine-specific Neurograms in the Sensory Vagus Nerve. Bioelectronic Medicine, 3(1), 7-17

H.A. Silverman, M. Dancho, A. Regnier-Golanov, M. Nasim, M. Ochani, P.S. Olofsson, M. Ahmed, E.J. Miller, S.S. Chavan, E. Golanov, C.N. Metz, K.J. Tracey, and V.A. Pavlov. (2015). Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation; Molecular Medicine, 20:601-11.
DOI: 10.2119/molmed.2014.00147


Expand All
Harold Silverman assists the firm in biotechnology patent prosecution. Harold has over a decade of experience in the area of bioelectronic medicine, including vagus nerve recording and stimulation. His experience also spans neurophysiology, neuromodulation, immunology, epidemiology, genetics, and biomedical anthropology.

A neuroscience enthusiast, Harold is passionate about applying his knowledge and experience in the integration of biology and technology to identify and advance projects with high potential for positive impact in the scientific, academic, and medical communities. He has a particular focus on working with start-ups to evaluate and accomplish their scientific and business goals.

Prior to joining Wolf Greenfield, Harold received his PhD in The Molecular Basis of Medicine from Zucker School of Medicine at Hofstra/Northwell, with a focus on the interaction between the nervous system and immune system in response to inflammation. As a graduate student researcher in the Feinstein Institutes Laboratory for Biomedical Sciences, he was involved in research discoveries that led to two preliminary patents.
  • Society for Neuroscience
  • New York Academy of Sciences

Scientific Publications

Yang, H., Zeng, Q., Silverman, H.A., Gunasekaran, M., George, S.J., Devarajan, A., Addorisio, M.E., Li, J., Tsaava, T., Shah, V. and Billiar, T.R., Wang, H., Brines, M., Andersson, U., Pavlov, P.A., Chang, E.H., Chavan, S.S., Tracey, K.J. (2021). HMGB1 released from nociceptors mediates inflammation. Proceedings of the National Academy of Sciences, 118(33).
DOI: 10.1073/pnas.2102034118

Silverman H.A., Chen A., Kravatz N.L., Chavan S.S., Chang E.H. (2020). Involvement of neural transient receptor potential channels in peripheral inflammation. Frontiers in Immunology, 11. eCollection 2020.
DOI: 10.3389/fimmu.2020.590261

Tsaava, T., Datta-Chaudhuri, T., Addorisio, M.E., Masi, E.B., Silverman, H.A., Newman, J.E., Imperato, G.H., Bouton, C.E., Tracey, K.J., Chavan, S.S., Chang, E.H. (2020). Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation. Bioelectronic Medicine, 6(1), 1-10.
DOI: 10.1186/s42234-020-00042-8

Lehner K.R., Silverman H.A., Addorisio M.E., Roy A., Al-Onaizi M.A., Levine Y., Olofsson P.S., Chavan S.S., Gros R., Nathanson N.M., Al-Abed Y.A., Metz C.N., Prado V.F., Tracey K.J., Pavlov V.A. (2019). Forebrain cholinergic signaling regulates innate immune responses and inflammation. Frontiers in Immunology. 10, 585.
DOI: 10.3389/fimmu.2019.00585

Zanos, T.P.*, Silverman H.A.*, Levy, T., Battinelli, E.A., Chavan, S.S., Tracey, K.J., Bouton, C.E. (2018). Identification of cytokine-specific neural signals by decoding murine vagus nerve activity. Proceedings of the National Academy of Sciences, 115 (21) E4843-E4852. DOI:10.1073/pnas.1719083115

Silverman, H.A., Stigler, A., Tsaava, T., Newnan, J., Steinberg, B.E., Battinelli, E.A., Robbiati, S., Bouton, C., Huerta, P.T., Chavan, S.S., Tracey, K.J. (2018). Standardization of methods to record vagus nerve activity in mice. Bioelectronic Medicine, 4(1), 1-13.
DOI: 10.1186/s42234-018-0002-y

Zaghloul N., Addorisio M., Silverman H.A., Patel H.L., Valdes Ferrer S.I., Ayasolla K.R., Lehner K.R.,Olofsson P.S., Nasim M., Metz C.N., Wang P., Ahmed M., Chavan S.S., Diamond B., Tracey K.J., Pavlov V.A.* (2017). Forebrain cholinergic dysfunction and systemic and brain inflammation in murine sepsis survivors. Frontiers in Immunology, 8.
DOI: 10.3389/fimmu.2017.01673

Caravaca, A.S., Tsaava, T., Goldman, L., Silverman, H., Riggott, G., Chavan, S., Bouton, C., Tracey, K.J., Desimone, R., Boyden, E., Sohal, H.S. and Olofsson, P.S. (2017). A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. Journal of Neural Engineering. 14(6), 066005.
DOI: 10.1088/1741-2552/aa7a42

Steinberg, B.E.*, Silverman, H.A.*, Robbiati, S., Gunasekaran, M.K., Tsaava, T., Battinelli, E., Stiegler, A., Bouton, C.E., Chavan, S.S., Tracey, K.J. and Huerta, P.T. (2016). Cytokine-specific Neurograms in the Sensory Vagus Nerve. Bioelectronic Medicine, 3(1), 7-17

H.A. Silverman, M. Dancho, A. Regnier-Golanov, M. Nasim, M. Ochani, P.S. Olofsson, M. Ahmed, E.J. Miller, S.S. Chavan, E. Golanov, C.N. Metz, K.J. Tracey, and V.A. Pavlov. (2015). Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation; Molecular Medicine, 20:601-11.
DOI: 10.2119/molmed.2014.00147